灌注系統概述
HSE—HA生理學系統是一系列應用廣泛的完備產品，可用于整體動物生理學、立體或在體器官和組織灌注及組織浴槽研究。這些系統具有廣泛的應用，包括傳統的**藥理學、DMPK、毒理學、呼吸系統、心臟病學、分子生物學和生理學。每個系統都設計了標準的組件，再加一些其他配置以適合特殊研究的需要。。標注組件也意味著如果你是需要將現有設備配齊，或者進行系統升級，或者是完整的配套產品，你都只需要購買需要的構件。HSE-HA生理學系統為你提供各種工具，使你的研究走向多產和成功。
我們提供大多數生理學檢測設備，包括放大器、電極、傳感器和電化學檢測器。參數包括力、位移、壓力、液體和氣體流、心電圖（單導聯—12導聯系統）、MAP（單個或多個部位）、腦電圖、肌電圖、連續支流灌注傳統的血氣參數和電解質的分析，可以選擇程序化軟件和傳統的刺激器作為放大器、電極和傳感器等產品的補充。
HSE-DAQ系統產品家族（BDAS、ACAD、HAEMODYN、ISOHEART、PULMODYN、PENNOCK）可以記錄你的初始信號，計算到處的參數，注釋數據，快速簡易的輸入確定的數據用于分析。同時還可以選擇用于進一步分析的軟件模塊，帶狀記錄紙打印，自動和控制模塊等。產品經過預先設置，打開包裝即可使用，并專門設計符合你的系統配置和數據分析要求。
• Investigation of ventilation and perfusion in the isolated rabbit lung
• Optimized in-situ preparation
• Negative-pressure ventilation to mimic closely the in-vivo situation
• Regular induction of hyperinflation of the lung (sigh)
• Perfusion under constant flow condition using buffer solution or blood
• Continuous measurement of lung mechanics (tidal volume, resistance, compliance), and perfusate characteristics (pressure, pCO2, pO2, pH)
• Continuous measurement of lung weight changes (Edema)
Ventilation
When the lung is placed in the artificial thoracic chamber and ventilated at negative pressure, the ventilation head is removed and replaced by the pneumotachometer for the measurement of respiratory flow. The ventilation medium (air or gas mixture) is constantly flowing past the distal end of the pneumotachometer. The breathing frequency can be varied between 30 and 60 breaths/min. In addition, the inspiratory time as a percentage of each breath, can be set between 10 and 90% in 10% steps. The end-inspiratory, end-expiratory, and deep breath (hyperinflationary) negative pressure can be set individually. A deep breath is usually induced every 5 to 20 min.
Constant Flow Perfusion
The constant flow rate of perfusate into the pulmonary artery is determined by a roller pump. The perfusate is stored in a water-jacketed container to maintain constant temperature. Aeration is provided to keep the pH constant. A heat exchanger and a bubble trap are placed next to the pulmonary artery connection for exact adjustment of the perfusate temperature just before the thorax chamber and to prevent air bubbles entering the lung.
Different perfusates can be provided in turn by transferring the suction tube from one reservoir to another; there is no need for prior aeration or temperature control. The use of oxygen-sensitive test substances raises few problems since the contact time with the high oxygen concentration is minimized. It is also possible to vary the gas mixture rapidly during the study.
A Constant Pressure Perfusion System is optionally available. Please call for details.
Lung Mechanics
The pressure inside the thoracic chamber is measured with a MPX pressure transducer. Air flow is determined with the pneumotachometer connected to a Validyne differential pressure transducer DP 45-14. The volume is derived from the air flow by integration. The calculation of pulmonary compliance and resistance needs a computer controlled data acquisition system (HSE-HA Pulmodyn).
• Investigation of ventilation and perfusion in the isolated rabbit lung
• Optimized in-situ preparation
• Negative-pressure ventilation to mimic closely the in-vivo situation
• Regular induction of hyperinflation of the lung (sigh)
• Perfusion under constant flow condition using buffer solution or blood
• Continuous measurement of lung mechanics (tidal volume, resistance, compliance), and perfusate characteristics (pressure, pCO2, pO2, pH)
• Continuous measurement of lung weight changes (Edema)